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does tpha become negative after syphilis treatment

PAST HISTORY : a 30 yr male with h/o sexual contact has TPHA positive and had taken doxycycline for two weeks but TPHA HAS NOT BECOME NEGATIVE,what should be done to get TPHA become negative

1 Answers

Dr. Puneet Madan answered : 12 years ago

Hi,

Tpha test is a treponemal test and it detects antibody against the antigen,so it can't go negative even after treatment also.
If you want to see the effect of treatment then vdrl test would usually go negative after the treatment.

However it is dependent what type of syphillis is there primary,secondary,or tertiary or latent because tpha comes down a little in secoundary syphillis(that is also not definitive but has been seen to come down in a few cases).

Feel free to ask further questions

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does tpha become negative after syphilis treatment

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